代表性论文与著作
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· Circularized Supramolecular Spherical Nucleic Acids Alleviates Liver Fibrosis through Blocking Upstream Activation and Reversing Activation State of Hepatic Stellate Cells
Yao Xu, Yu Fan, Zinan Zhao, Yuyan Qian, Wei Hu, Yong Hu*
ACS Nano, 2025, 10.1021/acsnano.4c15562.
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· Acid-resistant chemotactic DNA micromotors for probiotic delivery in inflammatory bowel disease
Zinan Zhao, Yao Xu, Yong Hu*
Nature Communications, 2025, 16, 3778.
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· Coordination of Functional Oligonucleotides Yields a Versatile Nanocomposite Microneedle Patch to Facilitate Local Wound Microenvironment Remodeling via Systemic Hyperglycemia Regulation.
Yuyan Qian, Beibei Zhang, Yao Xu, Junhao Liang, Xingsen Yang, Yifan Gu, Zhen Fan, Dong Li, and Yong Hu*
Advanced Functional Materials, 2025, 2423012
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· Aptamer-Directed Bidirectional Modulation of Vascular Niches for Promoted Regeneration of Segmental Trachea Defect.
Runfeng Cao, Zhenying Chen, Qing Ye, Weiyan Sun, Weikang Lin, Hai Tang, Xingseng Yang, Junhao Liang, Yi Chen, Lei Wang, Qingfeng Bai, Ziying Pan, Yulong Hu, Dong Xie*, Deping Zhao*, Yong Hu*, Chang Chen*
Advanced Functional Materials, 2025, 35, 2409071. (Inside Front Cover).
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· Transvascular Transport of Nanocarriers for Tumor Delivery.
Xin Li, Yong Hu, Xingcai Zhang*, Xiangyang Shi, Wolfgang J. Parak* & Andrij Pich*
Nature Communications, 2024, 15, 8172.
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· Polyaptamer-Driven Crystallization of Alendronate for Synergistic Osteoporosis Treatment through Osteoclastic Inhibition and Osteogenic Promotion.
Xingsen Yang, Yu Fan, Junhao Liang, Runfeng Cao, Beibei Zhang, Jianhua Li, Zejuan Li, Shisheng He, Na Liu, Jianzhong Du*, Yong Hu*
ACS Nano, 2024, 18, 33, 22431-22443.
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· Polymer mechanochemistry in drug delivery: From controlled release to precise activation.
Zhiyuan Shi*, Yong Hu*, Xin Li*
Journal of Controlled Release, 2024, 365, 259-273.
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· Injectable DNA Hydrogels with Intrinsic Antioxidant and Anti-Inflammatory Functions for Effectively Healing Bacteria Infected Diabetic Wounds.
Junhao Liang, Xingsen Yang, Chang Li, Beibei Zhang, Danqing Liu, Yu Fan*, Yong Hu*, and Jianzhong Du*
Chemistry of Materials, 2023, 35, 9963-9977.
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· The complex polymer architectures enabled by site-controlled polymerization on nucleic acids.
Yu Fan, Yong Hu*.
Matter, 2023, 6, 4121-4127.
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· One-pot synthesis of storage-stable, tumor-specific cascade DNA nanobioreactors for ultrasound-promoted synergistic therapy.
Gao He, Ziwei Zhang, Yanhui Zhu, Xiafei Yu, Fangze Qian, Xiaoqiang Zhang, Yu Luo, Xiang Li*, Xiaoan Liu*, Yong Hu*
Nano Today, 2023, 52, 101969.
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· Programming Injectable DNA Hydrogels Yields Tumor Microenvironment-Activatable and Immune-Instructive Depots for Augmented Chemo-Immunotherapy.
Yu Fan, Mengsi Zhan, Junhao Liang, Xingsen Yang, Beibei Zhang, Xiangyang Shi*, Yong Hu*.
Advanced Science, 2023,10, 2302119.
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· Nanomedicine‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma.
Yi Lu#, Yue Gao#, Huan Yang, Yong Hu*, Xin Li*.
Military Medical Research, 2022, 9, 69.
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· Engineered living hydrogels for robust biocatalysis in pure organic solvents.
Liang Gao, Lilin Feng, Daniel F. Sauer, Malte Wittwer, Yong Hu*, Johannes Schiffels*, Xin Li*.
Cell Reports Physical Science, 2022, 3, 101054. (封面文章, Matter专题报道).
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· A wireless and battery-free DNA hydrogel biosensor for wound infection monitoring.
Xin Li, Yi Lu, Yong Hu*.
Matter, 2022, 5, 2473-2475.
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· DNA membrane nanopores with highly tunable shapes and sizes.
Qian Ren, Yong Hu*.
Chem, 2022, 8, 1799-1801.
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· Nanocomposite DNA Hydrogels Emerging as Programmable and Bioinstructive Materials Systems.
Yong Hu*, Chunhai Fan.
Chem, 2022, 8, 1554-1566.
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· Postsynthetic Functionalization of DNA-Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applications.
Yong Hu, Carmen M. Domínguez, Sophina Christ, Christof M. Niemeyer*.
Angewandte Chemie International Edition, 2020, 59, 19016-19020. (Hot paper).
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· Carbon-Nanotube Reinforcement of DNA-Silica Nanocomposites Yields Programmable and Cell-Instructive Biocoatings.
Yong Hu, Carmen M. Domínguez, Jens Bauer, Simone Weigel, Alessa Schipperges, Claude Oelschlaeger, Norbert Willenbacher, Stephan Keppler, Martin Bastmeyer, Stefan Heißler, Christof Wöll, Tim Scharnweber, Kersten S. Rabe, Christof M. Niemeyer*.
Nature Communications, 2019, 10, 5522. (通过将两种不同形貌的纳米颗粒交联进入可编程的DNA水凝胶中，首次成功地实现对DNA水凝胶材料理化性能的动态调整，进而达到对哺乳动物细胞黏附、迁移、分裂等行为的控制。Technology Networks, Phys.org, Nanowerk, EurekAlert!, LaborPraxis, Bionity, ScienceDaily, BeScienced,KIT press等多家国际知名学术媒体以“Programmable Nests for Cells”为标题对本研究进行报道和转载).
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· Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres.
Yong Hu, Maximilian Grösche, Sahana Sheshachala, Claude Oelschlaeger, Norbert Willenbacher, Kersten S. Rabe, Christof M. Niemeyer*.
Angewandte Chemie International Edition, 2019, 58, 17269-17272.
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· From DNA Nanotechnology to Material Systems Engineering.
Yong Hu, Christof M. Niemeyer*.
Advanced Materials, 2019, 31, 1806294. (内封底文章).
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· Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy.
Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, Xiangyang Shi*.
Chemical Society Reviews, 2018, 47, 1874-1900. (ESI高被引文章).
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· Cultivation of Exoelectrogenic Bacteria in Conductive DNA Nanocomposite Hydrogels Yields a Programmable Biohybrid Materials System.
Yong Hu, David Rehnlund, Edina Klein, Johannes Gescher, Christof M. Niemeyer*.
ACS Applied Materials & Interfaces 2020, 12, 14806-14813.（首次成功地将有生命的产电细菌和无生命的导电水凝胶整合在一起，制备出“活性材料”（living materials），操控微生物机器人供电（Microbial Cyborgs: Bacteria Supplying Power）。该材料表现出优异的电化学特性，可以生成电子并将其高效地传输到电极上，因此有望被用在生物电化学传感器、生物电化学反应器、微生物燃料电池等系统。ACS pressPacs, Environmental News Network, New Atlas, Technology Networks, Phys.org, Nanowerk, EurekAlert! LaborPraxis, Bionity, ScienceDaily, Innovations Report , KIT press, Laboratory News, AlphaGalileo, ChemistryViews等国际知名学术媒体对本研究进行了多角度报道）.
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· Biomedical DNA hydrogels.
Yong Hu*.
Soft Science, 2022, 2, 3.（封面文章）.
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· Homopolymer nanobowls with controlled size and denting degree.
Tong Wu, Hui Sun, Jinhui Jiang, Sha Lin, Liujie Fan, Kai Hong, Qingmei Sun, Yong Hu*, Yunqing Zhu*, Jianzhong Du*.
Polymer Chemistry, 2022, 13(9), 1236-1242.
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· Self-Assembly of DNA Molecules: Towards DNA Nanorobots for Biomedical Applications.
Yong Hu*.
Cyborg and Bionic Systems, 2021, 2021 (0), 9807520.
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· Designer DNA-silica/carbon nanotube nanocomposites for traceable and targeted drug delivery.
Yong Hu, Christof M. Niemeyer*.
Journal of Materials Chemistry B, 2020, 8(11), 2250-2255.
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· Formulation of DNA Nanocomposites: Towards Functional Materials for Protein Expression.
Alessa Schipperges; Yong Hu; Svenja Moench; Simone Weigel; Johannes Reith; Diana Ordoñez-Rueda; Kersten S. Rabe; Christof M. Niemeyer*.
Polymers, 2021, 13(15), 2395.
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· Complex nucleic acid hybridization reactions inside capillary-driven microfluidic chips.
Marie L. Salva, Marco Rocca, Yong Hu, Emmanuel Delamarche, Christof M. Niemeyer*.
Small, 2020, 16, 2005476.
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· Segregation of dispersed silica nanoparticles in microfluidic water in oil droplets: A kinetic study.
Sahana Sheshachala, Maximilian Grösche, Tim Scherr, Yong Hu, Pengchao Sun, Andreas Bartschat, Ralf Mikut, Christof M. Niemeyer*.
ChemPhysChem. 2020, 21, 1070-1078.
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· Folic acid-modified Laponite®-stabilized Fe3O4 nanoparticles for targeted T2-weighted MR imaging of tumor.
Ling Ding, Ruizhi Wang, Yong Hu, Fanli Xu, Ni Zhang, Xueyan Cao, Xiaolin Wang, Xiangyang Shi, Rui Guo*.
Applied Clay Science, 2020, 186, 105447.
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· Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis.
Xin Li, Shiyi Lu, Zuogang Xiong, Yong Hu, Dan Ma, Wenqi Lou, Chen Peng*, Mingwu Shen*, Xiangyang Shi*.
Advanced Science, 2019, 6, 1901800.
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· Targeted dual-mode imaging and phototherapy of tumors using ICG-loaded multifunctional MWCNTs as a versatile platform.
Yong Hu#, Ruizhi Wang#, Yiwei Zhou#, Nuo Yu, Zhigang Chen, Dongmei Gao*, Xiangyang Shi*, Mingwu Shen*.
Journal of Materials Chemistry B, 2018, 6, 6122-6132.
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· Stacking of doxorubicin on folic acid-targeted multiwalled carbon nanotubes for in vivo chemotherapy of tumors.
Yan Yan#*, Ruizhi Wang#, Yong Hu#, Rongyue Sun, Tian Song, Xiangyang Shi*, Shimeng Yin*.
Drug Delivery, 2018, 25, 1607-1616.
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· Self-Assembling All-Enzyme Hydrogels for Flow Biocatalysis.
Theo Peschke, Patrick Bitterwolf, Sabrina Gallus, Yong Hu, Claude Oelschlaeger, Norbert Willenbacher, Kersten S. Rabe, Christof M. Niemeyer*.
Angewandte Chemie International Edition, 2018, 57, 17028-17032.（封面文章）
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· Radiotherapy-Sensitized Tumor Photothermal Ablation Using γ-Polyglutamic Acid Nanogels Loaded with Polypyrrole.
Yiwei Zhou, Yong Hu, Wenjie Sun, Shiyi Lu, Chao Cai, Chen Peng*, Jing Yu, Rachela Popovtzer*, Mingwu Shen, Xiangyang Shi*.
Biomacromolecules, 2018, 19, 2034-2042.
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· Dynamically tuning near-infrared-induced photothermal performances of TiO2 nanocrystals by Nb doping for imaging-guided photothermal therapy of tumors.
Nuo Yu#, Yong Hu#, Xiaoyong Wang, Gang Liu, Zhaojie Wang, Zixiao Liu, Qiwei Tian, Meifang Zhu, Xiangyang Shi*, Zhigang Chen*.
Nanoscale, 2017, 9(34), 9148-9159.
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· Using PEGylated iron oxide nanoparticles with ultrahigh relaxivity for MR imaging of an orthotopic model of human hepatocellular carcinoma.
Ruizhi Wang#, Yong Hu#, Yuchan Yang, Wei Xu, Mingrong Yao, Dongmei Gao, Yan Zhao, Songhua Zhan*, Xiangyang Shi*, Xiaolin Wang*.
Journal of Nanoparticle Research, 2017, 19, 39.
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· Facile Synthesis of Lactobionic Acid-Targeted Iron Oxide Nanoparticles with Ultrahigh Relaxivity for Targeted MR Imaging of an Orthotopic Model of Human Hepatocellular Carcinoma.
Yong Hu#, Ruizhi Wang#, Jingchao Li, Ling Ding, Xiaolin Wang*, Xiangyang Shi*, Mingwu Shen*.
Particle & Particle Systems Characterization, 2017, 34, 1600113.
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· Polyaniline-loaded γ-polyglutamic acid nanogels as a platform for photoacoustic imaging-guided tumor photothermal therapy.
Yiwei Zhou, Yong Hu, Wenjie Sun, Benqing Zhou, Jianzhi Zhu, Chen Peng*, Mingwu Shen, Xiangyang Shi*.
Nanoscale, 2017, 9, 12746-12754.
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· An RGD-modified hollow silica@Au core/shell nanoplatform for tumor combination therapy.
Xin Li, Lingxi Xing, Yong Hu, Zhijuan Xiong, Ruizhi Wang, Xiaoying Xu, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*.
Acta Biomaterialia, 2017, 62, 273-283.
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· Antifouling Manganese Oxide Nanoparticles: Synthesis, Characterization, and Applications for Enhanced MR Imaging of Tumors.
Peng Wang, Jia Yang, Benqing Zhou, Yong Hu, Lingxi Xing, Fanli Xu, Mingwu Shen, Guixiang Zhang*, Xiangyang Shi*.
ACS Applied Materials & Interfaces, 2017, 9, 47-53.
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· LAPONITE-Polyethylenimine Based Theranostic Nanoplatform for Tumor-Targeting CT Imaging and Chemotherapy.
Ying Zhuang, Lingzhou Zhao, Linfeng Zheng, Yong Hu, Ling Ding, Xin Li, Changcun Liu, Jinhua Zhao*, Xiangyang Shi*, Rui Guo*.
ACS Biomaterials Science & Engineering, 2017, 3, 431-442.
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· Multifunctional Fe3O4@Au core/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors.
Yong Hu, Ruizhi Wang, Shige Wang, Ling Ding, Jingchao Li, Yu Luo, Xiaolin Wang*, Mingwu Shen*, Xiangyang Shi*.
Scientific Reports, 2016, 6, 28325.
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· LAPONITE®-stabilized iron oxide nanoparticles for in vivo MR imaging of tumors.
Ling Ding#, Yong Hu#, Yu Luo, Jianzhi Zhu, Yilun Wu, Zhibo Yu, Chen Peng*, Xiangyang Shi*, Rui Guo*.
Biomaterials Science, 2016, 4, 474-482.
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· Facile Synthesis of Folic Acid-Modified Iron Oxide Nanoparticles for Targeted MR Imaging in Pulmonary Tumor Xenografts.
Zaixian Zhang#, Yong Hu#, Jia Yang, Yanhong Xu, Chengzhong Zhang, Zhongling Wang, Xiangyang Shi*, Guixiang Zhang*.
Molecular Imaging and Biology, 2016, 18, 569-578.
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· Synthesis of diatrizoic acid-modified LAPONITE® nanodisks for CT imaging applications.
Rania Mustafa#, Yong Hu#, Jia Yang, Jingwen Chen, Han Wang*, Guixiang Zhang*, Xiangyang Shi*.
RSC Advances, 2016, 6, 57490-57496.
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· Dendrimer-Stabilized Gold Nanostars as a Multifunctional Theranostic Nanoplatform for CT Imaging, Photothermal Therapy, and Gene Silencing of Tumors.
Ping Wei, Jingwen Chen, Yong Hu, Xin Li, Han Wang*, Mingwu Shen*, Xiangyang Shi*.
Advanced Healthcare Materials, 2016, 5, 3203-3213.
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· Folic acid-targeted iron oxide nanoparticles as contrast agents for magnetic resonance imaging of human ovarian cancer.
He Zhang, Jingchao Li, Yong Hu, Mingwu Shen, Xiangyang Shi*, Guofu Zhang*.
Journal of Ovarian Research, 2016, 9, 19.
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· Facile preparation of hyaluronic acid-modified Fe3O4@Mn3O4 nanocomposites for targeted T1/T2 dual-mode MR imaging of cancer cells.
Jingchao Li, Yong Hu, Wenjie Sun, Yu Luo, Xiangyang Shi*, Mingwu Shen*.
RSC Advances, 2016, 6, 35295-35304.
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· Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors.
Yong Hu#, Jia Yang#, Ping Wei, Jingchao Li, Ling Ding, Guixiang Zhang*, Xiangyang Shi*, Mingwu Shen*.
Journal of Materials Chemistry B, 2015, 3, 9098-9108.（Hot paper）
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· Facile synthesis of RGD peptide-modified iron oxide nanoparticles with ultrahigh relaxivity for targeted MR imaging of tumors.
Yong Hu#, Jingchao Li#, Jia Yang#, Ping Wei, Yu Luo, Ling Ding, Wenjie Sun, Guixiang Zhang*, Xiangyang Shi*, Mingwu Shen*.
Biomaterials Science, 2015, 3, 7211-732.（内封面文章）
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· Hyaluronic acid-modified Fe3O4@Au core/shell nanostars for multimodal imaging and photothermal therapy of tumors.
Jingchao Li#, Yong Hu#, Jia Yang#, Ping Wei, Wenjie Sun, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*.
Biomaterials, 2015, 38, 10-21.（ESI高被引文章）
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· Facile synthesis of folic acid-functionalized iron oxide nanoparticles with ultrahigh relaxivity for targeted tumor MR imaging.
Jingchao Li#, Yong Hu#, Jia Yang#, Wenjie Sun, Hongdong Cai, Ping Wei, Yaping Sun*, Guixiang Zhang, Xiangyang Shi*, Mingwu Shen*.
Journal of Materials Chemistry B, 2015, 3, 5720-5730.
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· Hyaluronic Acid-Modified Magnetic Iron Oxide Nanoparticles for MR Imaging of Surgically Induced Endometriosis Model in Rats.
He Zhang, Jingchao Li, Wenjie Sun, Yong Hu, Guofu Zhang*, Mingwu Shen*, Xiangyang Shi*.
PLoS ONE, 2014, 9, e94718.
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· Formation of multifunctional Fe3O4/Au composite nanoparticles for dual-mode MR/CT imaging applications.
Yong Hu, Jing-Chao Li, Ming-Wu Shen*, Xiang-Yang Shi*.
Chinese Physics B, 2014, 23, 078704.
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