代表性论文与著作

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· Host−Guest Assembly of Transmucosal Molecular Spherical Nucleic Acids for Oral Leukoplakia Immunotherapy and Microbiota Homeostasis Restoration.

Yao Xu, Zinan Zhao, Yiming Kong, Yu Fan*, Jun He, Zhen Fan, Guomin Wang, Yong Hu*.

JACS Au, 2026, https://doi.org/10.1021/jacsau.6c00012.

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· Immunoaffinity-Mimetic Assembly of Peptide-Aptamer Conjugates and Stem Cell-Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair.

Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia*, Rongrong Zhu*, Yong Hu*.  

Advanced Science, 2026, e19701.

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· Programming Molecular Switches within Capacitive PEDOT:DNA Hydrogels for Deciphering Pathophysiological Microenvironment Dynamics in Diabetic Wound.

Hao Wang, Zinan Zhao, Yao Xu, Yiming Kong, Dantong Zheng, Yang Xu, Sheng Chen*, Wei Chen*, Yong Hu*.  

Nano Letters, 2025, 25 (51), 17778–17789.

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· Inflammatory microenvironment-triggered oral mucositis treatment by guanosine microneedles.

Jianhua Li, Jialu Chen, Beibei Zhang, Pingyi Zhu, Xingsen Yang, Junhao Liang, Yuan He*, Yong Hu*, Jianzhong Du*.  

SCIENCE CHINA Materials, 2025, doi.org/10.1007/s40843-025-3782-0.

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· Double-Layer Nucleoside-Microneedles Co-Delivering Dexamethasone Vesicles and Adenosine Overcome Pseudomembrane Barriers for the Treatment of Oral Ulcer.

Beibei Zhang, Yuyan Qian, Jianhua Li, Yu Fan, Mingyuan Gao, Qianqian Wu, Zhouxiang Li, Yong Hu*, Jianzhong Du*

ACS Nano, 2025, 19 (27), 25204-25227.

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· Circularization of Aptamer Nanomedicine Improves Nuclease Resistance, Targeted Recognition, and Transdermal Effect for Topical Psoriasis Therapy

Zhe Liu, Yao Xu, Yuyan Qian, Yu Fan, Zhen Fan, Jianzhong Du*, Yong Hu*

Nano Letters, 2025, 25 (22), 9139–9148.

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· Circularized Supramolecular Spherical Nucleic Acids Alleviates Liver Fibrosis through Blocking Upstream Activation and Reversing Activation State of Hepatic Stellate Cells.

Yao Xu, Yu Fan, Zinan Zhao, Yuyan Qian, Wei Hu, Yong Hu*

ACS Nano, 2025, 19 (16), 15444-15456.

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· Acid-resistant chemotactic DNA micromotors for probiotic delivery in inflammatory bowel disease.

 Zinan Zhao, Yao Xu, Yong Hu*

 Nature Communications, 2025, 16, 3778.

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· Coordination of Functional Oligonucleotides Yields a Versatile Nanocomposite Microneedle Patch to Facilitate Local Wound Microenvironment Remodeling via Systemic Hyperglycemia Regulation.

Yuyan Qian, Beibei Zhang, Yao Xu, Junhao Liang, Xingsen Yang, Yifan Gu, Zhen Fan, Dong Li, and Yong Hu*

Advanced Functional Materials, 2025, 35 (23), 2423012

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· Aptamer-Directed Bidirectional Modulation of Vascular Niches for Promoted Regeneration of Segmental Trachea Defect.

Runfeng Cao, Zhenying Chen, Qing Ye, Weiyan Sun, Weikang Lin, Hai  Tang, Xingseng Yang, Junhao Liang, Yi Chen, Lei Wang, Qingfeng Bai,  Ziying Pan, Yulong Hu, Dong Xie*, Deping Zhao*, Yong Hu*, Chang Chen*

Advanced Functional Materials, 2025, 35, 2409071. (Inside Front Cover).

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· Transvascular Transport of Nanocarriers for Tumor Delivery.

 Xin Li, Yong Hu, Xingcai Zhang*, Xiangyang Shi, Wolfgang J. Parak* & Andrij Pich*

 Nature Communications, 2024, 15, 8172.

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· Polyaptamer-Driven Crystallization of Alendronate for Synergistic Osteoporosis Treatment through Osteoclastic Inhibition and Osteogenic Promotion.

Xingsen Yang, Yu Fan, Junhao Liang, Runfeng Cao, Beibei Zhang, Jianhua Li, Zejuan Li,  Shisheng He, Na Liu, Jianzhong Du*, Yong Hu*

ACS Nano, 2024, 18, 33, 22431-22443.

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· Polymer mechanochemistry in drug delivery: From controlled release to precise activation.

 Zhiyuan Shi*, Yong Hu*, Xin Li*

Journal of Controlled Release, 2024, 365, 259-273.

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· Injectable DNA Hydrogels with Intrinsic Antioxidant and Anti-Inflammatory Functions for Effectively Healing Bacteria Infected Diabetic Wounds.

Junhao Liang, Xingsen Yang, Chang Li, Beibei Zhang, Danqing Liu, Yu Fan*, Yong Hu*, and Jianzhong Du*

Chemistry of Materials, 2023, 35, 9963-9977.

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· The complex polymer architectures enabled by site-controlled polymerization on nucleic acids.

 Yu Fan, Yong Hu*.

 Matter, 2023, 6, 4121-4127.

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· One-pot synthesis of storage-stable, tumor-specific cascade DNA nanobioreactors for ultrasound-promoted synergistic therapy.

 Gao He, Ziwei Zhang, Yanhui Zhu, Xiafei Yu, Fangze Qian, Xiaoqiang Zhang, Yu Luo, Xiang Li*, Xiaoan Liu*, Yong Hu*

 Nano Today, 2023, 52, 101969.

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· Programming Injectable DNA Hydrogels Yields Tumor Microenvironment-Activatable and Immune-Instructive Depots for Augmented Chemo-Immunotherapy. 

Yu Fan, Mengsi Zhan, Junhao Liang, Xingsen Yang, Beibei Zhang, Xiangyang Shi*, Yong Hu*.

 Advanced Science, 2023,10, 2302119.

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· Nanomedicine‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma.

Yi Lu#, Yue Gao#, Huan Yang, Yong Hu*, Xin Li*.

Military Medical Research, 2022, 9, 69.

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· Engineered living hydrogels for robust biocatalysis in pure organic solvents. 

Liang Gao, Lilin Feng, Daniel F. Sauer, Malte Wittwer, Yong Hu*, Johannes Schiffels*, Xin Li*.

Cell Reports Physical Science, 2022, 3, 101054. (封面文章, Matter专题报道).

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· A wireless and battery-free DNA hydrogel biosensor for wound infection monitoring. 

Xin Li, Yi Lu, Yong Hu*.

Matter, 2022, 5, 2473-2475.

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· DNA membrane nanopores with highly tunable shapes and sizes. 

Qian Ren, Yong Hu*.

Chem, 2022, 8, 1799-1801.

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· Nanocomposite DNA Hydrogels Emerging as Programmable and Bioinstructive Materials Systems. 

Yong Hu*, Chunhai Fan.

Chem, 2022, 8, 1554-1566.

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· Postsynthetic Functionalization of DNA-Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applications.

Yong Hu, Carmen M. Domínguez, Sophina Christ, Christof M. Niemeyer*.

Angewandte Chemie International Edition, 2020, 59, 19016-19020. (Hot paper).

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· Carbon-Nanotube Reinforcement of DNA-Silica Nanocomposites Yields Programmable and Cell-Instructive Biocoatings. 

Yong Hu, Carmen M. Domínguez, Jens Bauer, Simone Weigel, Alessa Schipperges, Claude Oelschlaeger, Norbert Willenbacher, Stephan Keppler, Martin Bastmeyer, Stefan Heißler, Christof Wöll, Tim Scharnweber, Kersten S. Rabe, Christof M. Niemeyer*.

Nature Communications, 2019, 10, 5522. 

(Technology Networks, Phys.org, Nanowerk, EurekAlert!, LaborPraxis, Bionity, ScienceDaily, BeScienced,KIT press等多家国际知名学术媒体以“Programmable Nests for Cells”为标题对本研究进行报道和转载).

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· Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres.

Yong Hu, Maximilian Grösche, Sahana Sheshachala, Claude Oelschlaeger, Norbert Willenbacher, Kersten S. Rabe, Christof M. Niemeyer*.

Angewandte Chemie International Edition, 2019, 58, 17269-17272.

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· From DNA Nanotechnology to Material Systems Engineering.

Yong Hu, Christof M. Niemeyer*. 

Advanced Materials, 2019, 31, 1806294. (内封底文章).

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· Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy.

Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, Xiangyang Shi*. 

Chemical Society Reviews, 2018, 47, 1874-1900. (ESI高被引文章).

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· Cultivation of Exoelectrogenic Bacteria in Conductive DNA Nanocomposite Hydrogels Yields a Programmable Biohybrid Materials System.

Yong Hu, David Rehnlund, Edina Klein, Johannes Gescher, Christof M. Niemeyer*.

ACS Applied Materials & Interfaces 2020, 12, 14806-14813.（ACS pressPacs, Environmental News Network, New Atlas, Technology Networks, Phys.org, Nanowerk, EurekAlert! LaborPraxis, Bionity, ScienceDaily, Innovations Report , KIT press, Laboratory News, AlphaGalileo, ChemistryViews等国际知名学术媒体对本研究进行了多角度报道）.

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· Biomedical DNA hydrogels.

Yong Hu*.

Soft Science, 2022, 2, 3.（封面文章）.

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· Homopolymer nanobowls with controlled size and denting degree.

Tong Wu, Hui Sun, Jinhui Jiang, Sha Lin, Liujie Fan, Kai Hong, Qingmei Sun, Yong Hu*, Yunqing Zhu*, Jianzhong Du*.

Polymer Chemistry, 2022, 13(9), 1236-1242.

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· Self-Assembly of DNA Molecules: Towards DNA Nanorobots for Biomedical Applications.

Yong Hu*.

      Cyborg and Bionic Systems, 2021, 2021 (0), 9807520.

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· Designer DNA-silica/carbon nanotube nanocomposites for traceable and targeted drug delivery.

      Yong Hu, Christof M. Niemeyer*.

      Journal of Materials Chemistry B, 2020, 8(11), 2250-2255.

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· Formulation of DNA Nanocomposites: Towards Functional Materials for Protein Expression.

       Alessa Schipperges; Yong Hu; Svenja Moench; Simone Weigel; Johannes Reith; Diana Ordoñez-Rueda; Kersten S. Rabe; Christof M. Niemeyer*.

      Polymers, 2021, 13(15), 2395.

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· Complex nucleic acid hybridization reactions inside capillary-driven microfluidic chips.

       Marie L. Salva, Marco Rocca, Yong Hu, Emmanuel Delamarche, Christof M. Niemeyer*.

      Small, 2020, 16, 2005476.

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· Segregation of dispersed silica nanoparticles in microfluidic water in oil droplets: A kinetic study.

      Sahana Sheshachala, Maximilian Grösche, Tim Scherr, Yong Hu, Pengchao Sun, Andreas Bartschat, Ralf Mikut, Christof M. Niemeyer*.

      ChemPhysChem. 2020, 21, 1070-1078.

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· Self-Assembling All-Enzyme Hydrogels for Flow Biocatalysis.

      Theo Peschke, Patrick Bitterwolf, Sabrina Gallus, Yong Hu, Claude Oelschlaeger, Norbert Willenbacher, Kersten S. Rabe, Christof M. Niemeyer*.

      Angewandte Chemie International Edition, 2018, 57, 17028-17032.（封面文章）

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